The Y Combinator Era for Biotech

YC is now focused on biotech. Will VCs follow? Introduction: Both of these VC models are built for the old playbook for biopharma company formation: Two big changes have made it much cheaper to launch and scale biotech companies: The new playbook for biotech will be the YC fundraising model, as explained by Paul Graham:Continue reading “The Y Combinator Era for Biotech”

It’s 1994 Again

We are in the dot-com era for biotech. Introduction: For the last 25+ years, we have been living through one of the greatest technological revolutions ever, the Information Age. From Web 1.0 to Web 2.0 to Mobile to Web 3.0, the best startup founders and investors have ridden these waves to impact billions of peopleContinue reading “It’s 1994 Again”

The Front Door

We Need A YC for Everything This is Problem #3 on my list of The World’s Biggest Problems. The short answer is you need to know somebody. If you don’t already know one of them, you’re not getting in the front door. Those who do break through without connections take a grueling path to success,Continue reading “The Front Door”

The Money Problem

Money vs. Meaning Everyone has a number where they’d be financially ‘free’. The gap between this number and your current wealth is your money problem. Most people would quit if they had $100K+ to cover their next 1-2 years. This is Personal Capital. Many people need $10K or less to start their passion project. See:Continue reading “The Money Problem”

Y Combinator for Mittelstands

Both of these ideas are on my list of solutions to The World’s Biggest Problems. DM or email me if you want to invest! Summary: Accelerator: Invest the first $100K+ to help new pre-Mittelstands launch and grow. Ventures: Invest $1M+ to help pre-Mittelstands go from $1M to $10M+ revenue. Most VCs won’t fund niche servicesContinue reading “Y Combinator for Mittelstands”

We Need A Middle Class For Startups

Bootstrapped from zero. “Sell a product or course online! Sell services locally!” There are millions of different get rich quick schemes floating online now. The goal here is to secure the bag and escape the grind ASAP. Raised $100M+ from VCs. “Are you a Unicorn yet? Which Y Combinator class were you in?” Startups areContinue reading “We Need A Middle Class For Startups”

Best Quotes from the Becoming Warren Buffett Documentary

Notes: This HBO documentary covers the life and work of Berkshire Hathaway Chairman & CEO Warren Buffett, largely through his own quotes. We also hear a lot from his business partner Charlie Munger and his first wife Suzie Buffett. Warren Buffett’s advice can teach us way more about life than just business. Most people callContinue reading “Best Quotes from the Becoming Warren Buffett Documentary”

Public Ventures

How Governments Can Run VC Funds The public should get equity in businesses that take government funding. No more free-money bailouts for billionaires. Public VC funds share in the upside when the startups they fund succeed. This incentivizes governments to invest more in earlier-stage startups. Public VC is a renewable economic resource. Successful investments inContinue reading “Public Ventures”

43North for Detroit

Create a $5M+ per year fund sponsored by the City, State, and/or nonprofits. 43North invests $5M per year in startups that move to Buffalo. This accelerator is funded by the State of New York as part of its Buffalo Billion program. 43North’s Grand Prize winner gets a $1 million investment. Create thousands of jobs inContinue reading “43North for Detroit”

Arsenal of Progress

We don’t have enough food. We don’t have enough medicine. We don’t have enough masks. We don’t have enough semiconductor chips. We must have enough before we can dream of more. Literal factories. Hundreds of them. These factories of abundance are our new Arsenal of Progress. Movement: Detroit vs. Shenzhen Accelerator: YC for Manufacturing Fund:Continue reading “Arsenal of Progress”